TMEM43-S358L MUTATION ENHANCES NF-κB-TGFβ SIGNAL CASCADE IN ARRHYTHMOGENIC RIGHT VENTRICULAR DYSPLASIA/CARDIOMYOPATHY

TMEM43-S358L mutation enhances NF-κB-TGFβ signal cascade in arrhythmogenic right ventricular dysplasia/cardiomyopathy

Abstract Arrhythmogenic right ventricular dysplasia/cardiomyopathy (ARVD/C) is a genetic cardiac muscle disease that accounts for approximately 30% sudden cardiac death in young adults.The Ser358Leu mutation of transmembrane protein 43 (TMEM43) was commonly identified in the patients of highly lethal and fully penetrant ARVD subtype, ARVD5.Here, we

read more

The Reintroduction of Bobâlna Hill into the Tourist Circuit

Bobâlna Hill is the highest part of the Cluj and Dej Hills, an integrated part of the Someșan Plateau, with an altitude of 693 m.From a geomorphological point of view, it falls within the erosive-structural level formed on the horizon of the Dej tuff, of Lower Pannonian age.At the foot of the hill, a series of subsequent valleys developed, such a

read more